Fusion and Anti–inflammatory Activity of 6-bromo-2-(o-aminophenyl)-3-amino-Quinazolin-4(3H)-one from 6-bromo,2-(o-aminophenyl)-3,1-benzoxazin-4(3H)-one.

Volume 10, Issue 3, June 2025     |     PP. 62-72      |     PDF (302 K)    |     Pub. Date: December 1, 2025
DOI: 10.54647/chemistry150404    10 Downloads     122 Views  

Author(s)

Osarumwense Peter Osarodion, Department of Chemical Science, Ondo State University of Science and Technology, Okitipupa, Ondo State, Nigeria.

Abstract
Quinazolinone spin–off disclose various medicinal valuables such as analgesic, anti-inflammatory and anticancer activities, as well as antimicrobial activity. These heterocycles are beneficial intermediates in organic synthesis. Methods/Experimental: The compound, 6-bromo,2-(o-aminophenyl)-3,1-benzoxazin-4(3H)-one(1) was synthesized by dissolving 5-bromo anthranillic acid in 100 ml of pyridine. To this reaction mixture o-amino benzoyl chloride stirring at room temperature for 30 minutes this was refluxed with 75 mL of hydrazine hydrate for 3 hrs at 120-1300C. the reaction mixture was allowed to cool to room temperature to give 6-bromo-2-(o-aminophenyl)-3-amino-Quinazolin-4(3H)-one (2). These Compounds were appraise for their anti–inflammatory activity and the paw volume of each rat was dignified before 1 h and after 3 h of carrageenan treatment with the help of a plethysmometer. Study Design: This study was experimentally design and the synthesized compounds were masked and extimated pharmacologically for their in-vivo anti-inflammatory activity. Compound 1 had antiinflammatory activity of 61.75% and 71.53% at 20 mg/kg and 10 mg/kg respectively, while compound 2 had anti-inflammatory activity of 69.52% and 83.55% at 20 mg/kg and 10 mg/kg respectively. Result: The result shows that compound 2 synthesized had a higher anti-inflammatory activity than indomethacin which is a standard anti-inflammatory drug. Compound 2 had a higher antiinflammatory activity than Compound 1. Conclusions: From our findings, compound 2 synthesized had a higher anti-inflammatory activity than Compound 1 and Indomethacin, a standard anti-inflammatory drug.

Keywords
Anti–inflammatory activity; Quinazolinone derivatives; 6-bromo-2-(o-aminophenyl)-3-amino-Quinazolin-4(3H)-one; 6-bromo,2-(o-aminophenyl)-3,1-benzoxazin-4(3H)-one.

Cite this paper
Osarumwense Peter Osarodion, Fusion and Anti–inflammatory Activity of 6-bromo-2-(o-aminophenyl)-3-amino-Quinazolin-4(3H)-one from 6-bromo,2-(o-aminophenyl)-3,1-benzoxazin-4(3H)-one. , SCIREA Journal of Chemistry. Volume 10, Issue 3, June 2025 | PP. 62-72. 10.54647/chemistry150404

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